
职称:副教授
Email:gaocynk@163.com
研究方向:生物无机化学
个人简介
高春艳,女,党员,副教授,硕士研究生导师。目前主要从事生物无机化学的研究。
学习工作经历
2008/09 - 2013/06,南开大学,化学学院,无机化学专业,硕博连读,获理学博士学位
2004/09 - 2008/06,安阳师范学院,化学化工学院,化学教育专业,本科,获理学学士学位
2013/07 - 2016/12,山西农业大学,基础部,化学系,讲师
2016/12 - 至今,山西农业大学,基础部,化学系,副教授
教学科研概述
教学方面,承担本科生《无机及分析化学》,《无机化学实验》,《无机及分析化学实验》等课程。科研方面,主要从事抗肿瘤金属药物的合成及活性测定的研究。
发表论文
1. Guang-Huan Liu, Meng-Ze Li, Xin-Yue Cui, Yong-Po Zhang*, Jin-Zhong Zhao*, Ai-Qin Yue, Wei-Jun Du, Chun-Yan Gao*. Azido acetylated-glucosamine Schiff base copper complexes accumulate in cancer cells and induce apoptosis in vitro:High selective cytotoxicity against HepG-2 cells. Journal of Molecular Structure, 2025, 1338, 142348.
2. 张永坡,李鑫峰,宋亚菲,孙萌瑶,殷丛丛,高春艳*,赵晋忠*.基于共轭驱动的Cu(II)氧化仲胺合成氯桥联双核Cu(I)配合物.大学化学, 大学化学, 2024, 39(05): 44-51.
3. 贺卿,黄伟,周鑫慧,刘广欢,高春艳*,张永坡,杨美红,赵晋忠,杜维俊. 新型喹啉基铜配合物抑制HeLa细胞的增殖、迁移和侵袭.南开大学学报(自然科学版), 2024, 57(02):56-63.
4. Yong-Po Zhang, Yue-Wei Tian, Jiang Geng, Xin-Hui Zhou, Meng-Ze Li, Guang-Huan Liu, Chun-Yan Gao*, Ai-QinYue, Jin-Zhong Zhao*, Wei-Jun Du*. Nattokinase Enhances the Sensitivity of Cancer Cells to Oxaliplatin through Mitochondrial Pathway and Induction of Apoptosis, Arabian Journal of Chemistry, 2024, 17(1) 105478.
5. Yong-Po Zhang, Qing He, Xin-Hui Zhou, Guang-Huan Liu, Ai-Qin Yue, Chun-Yan Gao*, Jin-Zhong Zhao*, Wei-Jun Du*, Shi-Ping Yan, In situ reduction synthesis of quinoline-based copper(I) complexes: “Self-activating” chemical nuclease, antioxidation and anticancer activity. Journal of Molecular Structure. 2023, 1292, 136090.
6. Yong-Po Zhang*#, Qing He#, Yan-Yang Zhao, Pei-Pei Qiao, Yue-Wei Tian, Chun-Yan Gao*, Jin-Lei Tian, Wei-Jun Du* and Shi-Ping Yan, New dinuclear cobalt(II) complexes as “self-activating” chemical nuclease and inhibitor of tumor cell invasion: High selective cytotoxicity against NCI-H460 cells. Applied Organometallic Chemistry. 2023, e7074.
7. Yong-Po Zhang#, Zhong-Ying Ma#, Pei-Pei Qiao, Chun-Yan Gao*, Jin-Lei Tian*, Jin-Zhong Zhao, Wei-Jun Du, Jing-Yuan Xu* and Shi-Ping Yan, Copper based metallonucleases as potential antitumor drugs: Synthesis, Structure, in vitro Cytotoxicity and Apoptosis inducing properties. Journal of Molecular Structure, 2021, 1236,130278.
8. Yong-Po Zhang#, Zhong-Ying Ma#, Pei-Pei Qiao, Chun-Yan Gao*, Jin-Lei Tian*, Jin-Zhong Zhao,Wei-Jun Du, Jing-Yuan Xu*, Shi-Ping Yan, Design and biological evaluations of mono- and di-nuclear copper(II) complexes: Nuclease activity, cytotoxicity and apoptosis. Polyhedron, 2021, 193, 114880.
9. 乔佩佩,田玥玮,贺卿,张永坡,高春艳*,赵晋忠,杜维俊*. 多吡啶类双核镍配合物的合成、晶体结构及抗癌活性.无机化学学报, 2021, 37(10): 1738-1744.
10. Gao Chun-Yan, Qiao Pei-Pei, Yang Huang-Ze, Zhang Peng-Fei, Lei Yun-Bo, Zhang Yong-Po, Wang Min, Yue Ai-Qin, Zhao Jin-Zhong, Du Wei-Jun. Synthesis, Structure, DNA interaction and Cytotoxicity of Pyridine-Based Mononuclear Cobalt(II) Complex. Chinese Journal of Inorganic Chemistry, 2020, 36(9): 1783-1790.
11. Yue Ai-Qin, Zhang Yu-Ting, Zhang Peng-Qian, Gao Yuan-Yuan, Zhang Yong-Po, Wang Min, Gao Chun-Yan*, Zhao Jin-Zhong, Du Wei-Jun*. Two copper complexes with dpa-based ligand: syntheses, structures, nuclease activity and cytotoxicity. Chinese Journal of Inorganic Chemistry, 2017, 33(12): 2287-2295.
12. Zhang Yong-Po, Yang Jia-Jia, Lv Jia-Yuan, Gao Chun-Yan*, Zhao Jin-Zhong*, Synthesis, Structure, DNA/BSA binding and DNA cleavage of mononuclear manganese(II) and cobalt(II) complexes with N,O-chelating quinoline derivatived ligand. Chinese Journal of Inorganic Chemistry, 2016, 32(12): 2172-2182.
13. Chun-Yan Gao, Zhong-Ying Ma, Yong-Po Zhang, Si-Tong Li, Wen Gu, Xin Liu, Jin-Lei Tian*, Jing-Yuan Xu*, Jin-Zhong Zhao, Shi-Ping Yan, Four related mixedligand nickel (ii) complexes: effect of steric encumbrance on the structure, DNA/BSA binding, DNA cleavage and cytotoxicity. RSC Advances, 2015, 5(39): 30768-30779.
14. Chun-Yan Gao, Xin Qiao, Zhong-Ying Ma, Zhi-Gang Wang, Jing Lu, Jin-Lei Tian*, Jing-Yuan Xu*, Shi-Ping Yan, Synthesis, characterization, DNA binding and cleavage, BSA interaction and anticancer activity of dinuclear zinc complexes. Dalton Transactions, 2012, 41(39): 12220-12232.
15. Gao Chunyan, Ma Xiaofang, Lu Jing, Wang Zhigang, Tian Jinlei, Yan Shiping, Synthesis, structure, DNA binding, and cleavage activity of two copper (II) complexes, Journal of Coordination Chemistry, 2011, 64(12): 2157-2169.
16. Gao Chunyan, Ma Xiaofang, Tian Jinlei, Li Dongdong,Yan Shiping, Synthesis, structure, and DNA binding of three reduced amino-acid Schiff-base zinc (II), nickel (II), and cadmium (II) complexes, Journal of Coordination Chemistry, 2010, 63(1):115-123.
17. 乔佩佩,杜欣,刘广欢,张永坡,高春艳*,王敏,岳爱琴,赵晋忠,杜维俊*. 多吡啶双核铜配合物的合成、结构、核酸酶活性及体外细胞毒性.南开大学学报(自然科学版), 2021, 54(01):1-8.
18. 高春艳,白雪,高烨,杨佳佳,吕佳苑,张永坡,赵晋忠,多吡啶双核锌配合物的合成、结构、化学核酸酶活性及细胞毒性研究. 南开大学学报(自然科学版),2016,49(4):81-88.
19. 张永坡,吕佳苑,王玉峰,高春艳*,赵晋忠. 单核镍配合物的合成、结构、DNA/BSA键合、DNA切割及细胞毒性的研究. 南开大学学报(自然科学版),2016,49(2):77-83
20. 高春艳,冯莉,卢静,王志刚,田金磊,顾文,阎世平,水杨醛甘氨酸Schiff 碱铜配合物的合成、结构、磁性及其化学核酸酶活性研究. 南开大学学报(自然科学版),2011,(01):1-8+13.
21. 高春艳,马小芳,寇莹莹,李冬冬,冯莉,田金磊,阎世平,酪氨酸过渡金属配合物的合成、结构及其与DNA相互作用的光谱学研究. 南开大学学报(自然科学版),2009(4):103-110.
主持课题
1. 山西省高等学校教学改革创新项目(J20230434),“新农科”和“一流专业”建设背景下无机化学实验教学改革研究及实践。
2. 山西省应用基础研究项目青年科技研究基金(201701D221157),大豆异黄酮类糖苷金属配合物抗肿瘤活性的研究。
3. 山西农业大学引进人才科研启动费项目(No.2013YJ40),过渡金属配合物的合成及其生物活性研究。
4. 山西农业大学科技创新基金项目(No.2014013),铜、锌系列配合物的合成及其生物活性研究。
编写著作、教材
1. 教材:有机化学,赵晋忠主编. 普通高等教育"十二五"规划教材,北京:中国林业出版社 2015. 参编
2. 教材:无机及分析化学实验,张建刚/杨美红主编. 普通高等教育"十四五"规划教材,北京:中国林业出版社 2021. 参编
成果专利
高春艳,李柄金,贺卿,殷丛丛,郭冬冬,张永坡,赵晋忠,杜维俊. 一种具有抗肿瘤活性的亚铜配合物及其制备方法和应用,中国发明专利,202210516334.9。
获奖情况
1. 高春艳,贾俊仙. 原位还原Cu(II)合成Cu(I)——新型亚铜配合物的合成,第三届全国大学生化学实验创新设计大赛全国总决赛一等奖指导教师,2022.8。
2. 程作慧,赵晋忠,杨美红,高春艳,段慧娟. 2021年山西省教学成果奖(高等教育)一等奖,2021.11。