李鹏-基础部网站

职称：教授

邮箱：lip@sxau.edu.cn

研究方向：生物信息学

个人简介：

2004-2011年于西北大学生命科学学院获学士和硕士学位，2015年于西北农林科技大学生命科学学院获生物信息学博士学位，现任山西农业大学教授。

教学科研概述

教学方面：针对全校主讲生物化学、生物化学实验和化学生物学课程。

科研方面：感兴趣的研究方向包括系统生物学、生物信息学、药物筛选和中药作用机制研究。已发表学术论文30余篇；主持国家级课题2项，省部级课题4项；入选山西省三晋英才支持计划，山西农业大学晋农学者新秀奖；担任Pharmacological research、Front. Pharmacol、J Ethnopharmacol等多家SCI杂志审稿人。

发表论文

1. 李鹏*,张浩然,张元媛,詹灵敏,陈建新.基于整体化学和生物效应谱推演的中药靶点研究新模式及应用[J].中草药,2023,54(06):1986-1997

2. Li, P.; Hu, Y.; Zhan, L.; He,J.; Lu, J.; Gao, C.; Du, W.; Yue, A.;Zhao, J.; Zhang, W. A Natural Glucan from Black Bean Inhibits Cancer Cell Proliferation via PI3K-Akt and MAPK Pathway. Molecules 2023, 28(4):1971. https://doi.org/10.3390/molecules28041971.

3. Li P*, Bai C, Zhan L, Zhang H, Zhang Y, Zhang W, Wang Y and Zhao J (2023),Specific gene module pair-based target identification and drug discovery. Front. Pharmacol. 13:1089217. doi: 10.3389/fphar.2022.1089217

4. 李鹏*,张元媛,张浩然,詹灵敏,张武霞,白辰,陈建新.基于转录组数据解析麻杏石甘汤治疗肺炎的多尺度作用机制[J].中国实验方剂学杂志,2023,29(01):82-90.DOI:10.13422/j.cnki.syfjx.20221417.

5. Peng Li*, Haoran Zhang, Wuxia Zhang, Yuanyuan Zhang, Lingmin Zhan, Ning Wang, Caiping Chen, Bangze Fu, Jinzhong Zhao, Xuezhong Zhou, Shuzhen Guo, Jianxin Chen*, TMNP: a transcriptome-based multi-scale network pharmacology platform for herbal medicine, Briefings in Bioinformatics, 2022, 23(1); bbab542, https://doi.org/10.1093/bib/bbab542

6. Wuxia Zhang, Lei Wang, Ziwen Lu, Baofu Wang, Yang Li, Jingjing Yang, Jinxin Meng, Jinzhong Zhao, Mingjing Zhao*, andPeng Li*. Discovery of Natural Compounds for Cardiac Fibrosis by a Transcriptome-Based Functional Gene Module Reference Approach, J. Nat. Prod. 2020, 83 (10), 2923-2930, https://doi.org/10.1021/acs.jnatprod.0c00453.

7. Wang L, Zhang W, Lu Z, Wang B, Li Y, Yang J,Li P* and Zhao M*. Functional Gene Module–Based Identification of Phillyrin as an Anticardiac Fibrosis Agent. Front. Pharmacol. (2020)11:1077. doi: 10.3389/fphar.2020.01077.

8. Wuxia Zhang*, Yihua Hu, Jinzhong Zhao, Yongpo Zhang, Dongdong Guo, Chunyan Gao, Jinyou Duan,Peng Li*. Immunoregulation and antioxidant activities of a novel acidic polysaccharide from Radix Paeoniae Alba. Glycoconj J (05 March 2020) 37, 361–371.https://doi.org/10.1007/s10719-020-09916-0.

9. 张武霞;庄智彬;郭淑珍;李鹏*.特异性促炎症消退介质结构与功能研究进展. 免疫学杂志, 2020, 36(5): 88-97.

10. Yinglu Ren(#), Xiangyang Chen(#),Peng Li(#), Huimin Zhang, Congping Su, Zifan Zeng,Yan Wu, Xuan Xie, Qing Wang, Jing Han, Shuzhen Guo^⁎ , Bin Liu^⁎⁎, Wei Wang^⁎. Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice. Pharmacological research 2019,146:104318.

11. Li, Peng(#) (*)，Chen, Chang(#)，Zhang, Wuxia，Yu, Dingrong，Liu, Shaoyan，Zhao, Jinzhong， Liu, An(*)，Detection of Vasodilators From Herbal Components by a Transcriptome-Based Functional Gene Module Reference Approach，Frontiers in Pharmacology，2019，10:1144.

12. WangNing(#);Li，Peng(#); Hu，Xiaochen; Yang，Kuo; Peng，Yonghong; Zhu，Qiang; Zhang，Runshun; Gao，Zhuye; Xu，Hao; Liu，Baoyan; Chen，Jianxin(*); Zhou，Xuezhong(*). Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network. Computational and Structural Biotechnology Journal, 2019.2.8, 17: 282~290.

13. Li Peng(#); Chen Jing(#); Zhang Wuxia; Li Hongmei; Wang Wei; Chen Jianxin(*). Network pharmacology based investigation of the effects of herbal ingredients on the immune dysfunction in heart disease. Pharmacological research, 2018, 141: 104~113.

14. Li, Peng(#)(*)，Chen, Jianxin，Zhang, Wuxia，Fu, Bangze，Wang, Wei(*). Transcriptome inference and systems approaches to polypharmacology and drug discovery in herbal medicine.J Ethnopharmacol，2017.1.4，195：127~136.

15. Guo, Shuzhen(#)，Li, Peng(#)，Fu, Bangze(#)，Chuo, Wenjing(#)，Gao, Kuo，Zhang, Wuxia，Wang, Junyao，Chen, Jianxin(*)，Wang, Wei(*). Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia.Pharmacol Res，2016.12.1，114：196~208.

16. Li, Peng(#)，Huang, Chao(#)，Fu, Yingxue(#)，Wang, Jinan(#)，Wu, Ziyin，Ru, Jinlong，Zheng, Chunli，Guo, Zihu，Chen, Xuetong，Zhou, Wei，Zhang, Wenjuan，Li, Yan，Chen, Jianxin，Lu, Aiping，Wang, Yonghua. Large-scale exploration and analysis of drug combinations.Bioinformatics，2015.6.15，31（12）：2007~2016.

17. Li, Peng(#)，Fu, Yingxue，Wang, Yonghua(*). Network based approach to drug discovery: a mini review.M ini Rev Med Chem，2015.1.1，15（8）：687~695.

18. Li, Peng(#)，Fu, Yingxue(#)，Ru, Jinlong，Huang, Chao，Du, Jiangfeng，Zheng, Chunli，Chen, Xuetong，Li, Pidong，Lu, Aiping，Yang, Ling，Wang, Yonghua(*). Insights from systems pharmacology into cardiovascular drug discovery and therapy.BMC Syst Biol，2014.12.24，8：141~141.

19. Li, Peng(#)，Chen, Jianxin(#)，Wang, Jinan，Zhou, Wei，Wang, Xia，Li, Bohui，Tao, Weiyang，Wang, Wei(*)，Wang, Yonghua(*)，Yang, Ling. Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases.J Ethnopharmacol，2014.1.1，151（1）：93~107.

20. Yang, Ruocong#; Liu, Hao#; Bai, Chen#; Wang, Yingchao; Zhang, Xiaohui; Guo, Rui; Wu, Siying; Wang, Jianxun; Leung, Elaine; Chang, Hang;Li, Peng; Liu, Tiegang*; Wang, Yi*. Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study.Pharmacological Research, 2020, 157: 104820.doi:https://doi.org/10.1016/j.phrs.2020.104820.

21. Zhang L, Huang Y, Wu C, Du Y,Li P, Wang M, Wang X, Wang Y, Hao Y, Wang T, Fan B, Gao Z and Fu F (2019) Network Pharmacology Based Research on the Combination Mechanism Between Escin and Low Dose Glucocorticoids in Anti-rheumatoid Arthritis. Front. Pharmacol. 10:280. doi: 10.3389/fphar.2019.00280.

22. Zhang, Wuxia(#)(*); Chen, Lu; Li, Peng; Zhao, Jinzhong; Duan, Jinyou(*).Antidepressant and immunosuppressive activities of two polysaccharides from Poria cocos (Schw.) Wolf. International Journal of Biological Macromolecules, 2018.9.26, 120(Pt B): 1696~1704.

23. Jichun Han(#); Dong Wang(#); Lei Ye; Peng Li; Wenjin Hao; Xiaoyu Chen; Jun Ma; Bo Wang; Jing Shang; Defang Li(*); Qiusheng Zheng(*). Rosmarinic Acid Protects against Inflammation and Cardiomyocyte Apoptosis during Myocardial Ischemia/Reperfusion Injury by Activating Peroxisome Proliferator-Activated Receptor Gamma. Frontiers in Pharmacology, 2017.7.11, 8(456).

24. Zhang, W.,Li, P., Song, D., Niu, H., Shi, S., Wang, S., and Duan, J. Structural characterization and biological activities of two alpha-glucans from Radix Paeoniae Alba. Glycoconj J 2016,33,147-157.

25. Zhang, W., Dong, D.,Li, P., Wang, D., Mu, H., Niu, H., and Duan, J. (2016). Novel pH-sensitive polysialic acid based polymeric micelles for triggered intracellular release of hydrophobic drug. Carbohydr Polym 139, 75-81.

26. Li, Peng，Wang, Jinan，Zhou, Wei，Li, Bohui，Huang, Chao，Li, Pidong，Guo, Zihu，Tao, Weiyang，Yang, Yinfeng，Xu, Xue，Li, Yan，Wang, Yonghua，Yang, Ling. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.Ru, Jinlong(#)， J Cheminform，2014.1.1，6：13~13.

27. Yao, Yao(#); Zhang, Xiaodong; Wang, Zhenzhong; Zheng, Chunli;Li, Peng; Huang, Chao; Tao, Weiyang; Xiao, Wei; Wang, Yonghua(*); Huang, Luqi; Yang, Ling. Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction. Journal of Ethnopharmacology, 2013.11.25, 150(2): 619~638.

28. Zhou, Juan(#);Li, Peng; Cheng, Ni; Gao, Hui; Wang, Bini; Wei, Yahui(*); Cao, Wei(*). Protective effects of buckwheat honey on DNA damage induced by hydroxyl radicals. Food and Chemical Toxicology, 2012.6.7, 50: 2766~2773.

29. 王文娟(#)，任欢欢，韩吉春，王博，李鹏，郑秋生. 黄芩苷抗脑缺血再灌注损伤的作用机制.中国实验方剂学杂志，2016.1.5：113~116.

30. 王文娟(#)，任欢欢，韩吉春，王博，李鹏，郑秋生. 积雪草苷对缺血再灌注损伤的保护作用及其机制的研究.石河子大学学报(自然科学版)，2015.10.1：593~598.

主持课题

1、基于中药-疾病整体化学和生物效应谱推演的中药直接和间接靶点识别，国家自然科学基金面上项目，批准号：82274363，2023.01-2026.12，51万，主持。

2、基于非经典TGFβ-TAK1-p38通路的连翘苷干预心肌纤维化效应机制研究，山西省基础研究计划资助项目，批准号：20210302124129，2022.01-2025.01，9万，主持

3、基于periostin基因互作网络的抗心肌纤维化中药成分筛选及靶标识别，国家自然科学基金青年项目，批准号：81703945，2018.01-2020.12，20万，主持。

4、基于基因互作网络和药物表达谱的抗心肌纤维化药物组合发现，山西省高等学校科技创新项目，批准号：2019L0360，2019.05-2021.5，3万，主持。

5、基于网络药理学技术挖掘丹参治疗心血管疾病的特征成分组及其药理学靶标空间，山西农大创新基金，NO.2017YJ17,2017.08-2020.07，16万，主持。

专利

1、抗心肌纤维化药物的筛选方法与流程。李鹏，赵晋忠，张武霞，孟锦鑫，中国发明专利，专利号：201910818494.7.

2、一种治疗心脑血管疾病的中药及其制备方法.王永华，李鹏，汪纪楠，周伟,中国发明专利，专利号：ZL201310031971.8。

3、一种高分子量去乙酰化透明质酸的制备方法及其应用.段金友，张武霞，李鹏，王冬冬,中国发明专利，专利号：ZL201510309912.1。

软件著作权

1、中药多尺度生物效应分析平台,山西农业大学，李鹏，张浩然，张元媛，詹灵敏，登记号：2022SR0077810.

2、药物直接和间接靶点预测平台,山西农业大学;李鹏;张武霞;赵晋忠;张浩然;王澳义;张元媛;詹灵敏;王英东,登记号：2023SR1793070.